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WebIt is used to treat erectile dysfunction (ED). It is used to treat high blood pressure in the lungs. It may be given to you for other reasons. Talk with the doctor. What do I need to .The onset of action can occur within 30 minutes, while the duration of the effect can last up to 18 hours. Percentage of Patients Reporting an Improvement in Erections. Figure 6. The titration studies, in which most patients received mg, showed similar results. The major circulating metabolite results from N-desmethylation of sildenafil, and is itself further metabolized. Different brands may not work the same way. In a study of healthy male volunteers, sildenafil mg did not affect the steady state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates.WebPatient Information VIAGRA®(vi-AG-rah) (sildenafil citrate) Tablets What is the most important information I should know about VIAGRA? VIAGRA can cause your blood . WebIt is used to treat erectile dysfunction (ED). It is used to treat high blood pressure in the lungs. It may be given to you for other reasons. Talk with the doctor. What do I need to . WebIn the first eight months after it’s introduction, over 50 million Viagra tablets have been prescribed. Viagra has been found to be an extremely safe and effective treatment for .This medicine comes with a patient information leaflet. Therefore, inhibitors of these isoenzymes may reduce sildenafil clearance and inducers of these isoenzymes may increase sildenafil clearance. If too much is used, the chance of side effects is increased. The concomitant use of erythromycin or strong CYP3A4 inhibitors e. Adverse Effects Warnings and Precautions Sildenafil has systemic vasodilatory effects and, as such, should be prescribed with caution to patients who may be sensitive to such blood pressure changes, such as patients with left ventricular outflow obstruction and impaired autonomic control of blood pressure. However, the dose is usually not more than 80 mg 3 times a day.